{"id":9752,"date":"2022-04-06T17:36:53","date_gmt":"2022-04-06T22:36:53","guid":{"rendered":"https:\/\/iaf.care\/?p=9752"},"modified":"2022-12-14T10:21:42","modified_gmt":"2022-12-14T16:21:42","slug":"12-notable-krabbe-disease-treatment-options","status":"publish","type":"post","link":"https:\/\/iaf.care\/12-notable-krabbe-disease-treatment-options\/","title":{"rendered":"12 Notable Krabbe Disease Treatment Options"},"content":{"rendered":"\n

Krabbe disease treatment - Krabbe disease is a rare neurological disorder<\/a> that affects the nervous system. It is caused by a deficiency of the enzyme galactosidase A, which is responsible for breaking down a type of sugar called galactose. This leads to the accumulation of galactose in the tissues and organs, which can damage the cells and tissues.<\/p>\n\n\n

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\"Krabbe<\/figure><\/div>\n\n\n

Krabbe disease symptoms usually appear in infancy or early childhood. They may include difficulty swallowing and eating, muscle weakness, poor coordination, and seizures. Krabbe disease in adults can lead to death within a few months or years after diagnosis. However, treatment options are available that can improve the prognosis for some patients. There is currently no known cure for Krabbe syndrome.<\/p>\n\n\n\n

If a person or their loved one has been diagnosed with Krabbe disease, it is important to learn as much as they can about the condition and seek treatment options. They should talk to their doctor about what treatments may be available to them. There are also several support groups available for people affected by Krabbe disease. The Krabbe Disease Foundation is a good resource for information and support.<\/p>\n\n\n\n

Krabbe Disease Causes and Risk Factors<\/strong><\/h2>\n\n\n\n

Krabbe syndrome happens when a person inherits two copies of a mutated or altered gene. This means receiving a copy from each parent.<\/p>\n\n\n\n

A gene provides a type of map used for producing proteins. If there is a mistake on this map, then the protein product will most likely not function properly. With Krabbe disease, two altered copies of a particular gene result in minimal or no production of an enzyme called galactocerebrosidase (GALC).<\/p>\n\n\n\n

Enzymes, such as GALC, carry the responsibility for breaking down certain substances in a cell's recycling center (lysosome). In Krabbe disease, the short supply of GALC enzymes results in the accumulation of certain types of fats called galactolipids.<\/p>\n\n\n\n

Galactolipids usually exist in cells that produce the protective coating of nerve cells called myelin. However, the formation of too many galactolipids has a toxic effect. Some galactolipids trigger myelin-forming cells to self-destruct, which in turn causes more problems.<\/p>\n\n\n\n

Other galactolipids are taken up by specific debris-eating cells in the nervous system called microglia. The process of cleaning up the excess galactolipids transforms these typically helpful cells into abnormal, toxic cells called globoid cells. These cells promote myelin-damaging inflammation. The subsequent loss of myelin (demyelination) prevents nerve cells from sending and receiving messages.<\/p>\n\n\n\n

There is no known way to prevent Krabbe disease from occurring. However, there are some risk factors that may increase the chance of a person developing the condition.<\/p>\n\n\n\n

Risk factors for Krabbe disease include:<\/p>\n\n\n\n